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apalutamide will lower the extent or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medicine which are CYP3A4 substrates may result in decreased exposure to these prescription drugs.Been utilizing it for quite a while, I gene